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doi:10.1177/2333721416686019 GLP-1R Signaling Directly Activates Arcuate Nucleus Kisspeptin Action in Brain Slices but Does not Rescue Luteinizing Hormone Inhibition in Ovariectomized Mice During Negative Energy Balance

Phase 4: adaptation and stabilization (weeks 28 and beyond) The decline in heart rate effects after week 24 reflects genuine physiological adaptation

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3.3.4 MGBA alterations and pathophysiological mechanisms in anxiety Rodent models of anxiety disorders provide causal evidence that stress exposure disrupts the MGBA, leading to microbiota alterations, compromised gut barrier integrity, immune activation and neurotransmitter imbalance (Bear et al., 2021)

Diabetes 64 , 16881697 (2015)

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