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Specific metabolic changes observed during GLP-1 treatment include: Improved insulin sensitivity , allowing cells to use glucose more efficiently Reduced hepatic glucose production , contributing to better glycaemic control Changes in body composition , with loss of both fat mass and some lean tissue Alterations in lipid metabolism , often resulting in improved cholesterol profiles Body composition studies suggest that lean tissue loss typically accounts for approximately 20-30% of total weight lost during GLP-1 therapy, though this varies considerably between individuals and depends on concurrent physical activity and protein intake

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Mitochondrial Protection The mitochondrial pool of glutathione is separate from the cytosolic pool and is particularly vulnerable to depletion

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The pathogenesis of ARDS primarily involves excessive inflammation and damage to the alveolar-capillary barrier, resulting in the accumulation of inflammatory cells, increased levels of pro-inflammatory factors and injury to alveolar epithelial cells

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