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Given the potential compulsive component in patients with dysregulated eating behaviors, the delta-theta biomarker may not be applicable to the broader population with obesity
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In Phase 3 TRIUMPH-4, retatrutide at 12 mg produced 28.7% body weight loss at 68 weeks vs 2.1% for placebo
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Whether using oral or injectable formats, long-term success depends on consistent use, support from knowledgeable health care providers, and an understanding that weight regain is possible without continued commitment
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