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S.MarukalaN
doi:10.1093/gerona/glw132 T3 (Triiodothyronine), Total Triiodothyronine (T3) is the active form of thyroid hormone, with most of it bound to proteins and a small fraction circulating freely
The bulk of the evidence comes from animal and laboratory models
Attribution requires a single-subtype recombinant line, selective antagonist controls, or a selective agonist comparator such as setmelanotide for MC4R
However, over-nourished, sedentary modern lifestyles disrupt this system and can cause serious medical problems, which include metabolic syndrome, obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease
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