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Injecting contaminated solution introduces these organisms directly into subcutaneous tissue, potentially causing: Localized injection site reactions (redness, swelling, warmth) Abscess formation requiring medical drainage Cellulitis (spreading skin infection) In rare cases, systemic infection The risk is highest for vials that are significantly past their BUD, have been stored improperly, or have been punctured many times

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Among them, only lithocholate sulfate was simultaneously present in the differential metabolites of intestinal tissues and the causal relationships identified by MR (Supplementary Figures S2, S4), suggesting that this metabolite may act as a key mediator between the intestinal tract and blood circulation