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Most clinical use is based on extrapolation from animal research and anecdotal reports from clinical practice

Conversely, it may enhance the renal excretion of some drugs, such as amphetamines and certain tricyclic antidepressants, by acidifying the urine

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Br J Clin Pharmacol

The medicines being considered for reclassification are typically those that treat common, self-limiting conditions or those where the risk can be managed with pharmacy intervention

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