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Intrinsic toxicity of the cellular prion protein is regulated by its conserved central region
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Stadler, Wieland Kiess, Antje Garten Supplementary Tables Differentially Expressed Genes from RNA-seq Supplementary Table S1 - Differentially expressed genes adjusted p-value |1|: [csv] [xlsx] Supplementary Table S3 - Overlap of differentially expressed genes from three studies: [csv] [xlsx] Supplementary Tables S4 - SVF cell cultures: [S4] Supplementary Tables S5 - Antibodies used for flow cytometry: [S5] Supplementary Tables S6 - Flow cytometry analysis of cell surface markers [S6] Supplementary Tables S7 - crRNAs used for CRISPR/Cas9 PTEN knockout: [S7] Supplementary Tables S8 - Antibodies for Western blot and immunoflourescence staining: [S8] Supplementary Tables S7 - Primers used for RT-qPCR: [S9] Supplementary Figures Supplementary Figure 1 [S1] Supplementary Figure 2 [S2] Supplementary Figure 3 [S3] Supplementary Figure 4 [S4] Supplementary Figure 5 [S5] Supplementary Figure 6 [S6] Supplementary Figure 7 [S7] Gene Set Enrichment in KEGG Pathways Figure caption Enriched pathways Cellular Senescence - hsa04218 (Graphviz view) [pdf] - hsa04218 (KEGG view) [png] Proteoglycans in cancer - hsa05205 (Graphviz view) [pdf] - hsa05205 (KEGG view) [png] Endocytosis - hsa04144 (Graphviz view) [pdf] - hsa04144 (KEGG view) [png] Pathways in Cancer - hsa05200 (Graphviz view) [pdf] - hsa05200 (KEGG view) [png] Focal adhension - hsa04510 (Graphviz view) [pdf] - hsa04510 (KEGG view) [png] Rap1 signaling pathway - hsa04015 (Graphviz view) [pdf] - hsa04015 (KEGG view) [png] Sphingolipid signaling pathway - hsa04071 (Graphviz view) [pdf] - hsa04071 (KEGG view) [png] Spingolipid metabolism - hsa00600 (Graphviz view) [pdf] - hsa00600 (KEGG view) [png] FoxO signaling pathway - hsa04068 (Graphviz view) [pdf] - hsa04068 (KEGG view) [png] Apelin signaling pathway - hsa04371 (Graphviz view) [pdf] - hsa04371 (KEGG view) [png] Platelet activation - hsa04611 (Graphviz view) [pdf] - hsa04611 (KEGG view) [png] Synaptic vesicle circle - hsa04721 (Graphviz view) [pdf] - hsa04721 (KEGG view) [png] Insulin signaling pathway - hsa04910 (Graphviz view) [pdf] - hsa04910 (KEGG view) [png] Hepatocellular carcinoma - hsa05225 (Graphviz view) [pdf] - hsa05225 (KEGG view) [png] MAPKsignaling pathway - hsa04010 (Graphviz view) [pdf] - hsa04010 (KEGG view) [png] Adherence junction - hsa04520 (Graphviz view) [pdf] - hsa04520 (KEGG view) [png] Additional Relevant Pathways Glycolysis / Gluconeogenesis - hsa00010 (Graphviz view) [pdf] - hsa00010 (KEGG view) [png] Citrate cycle (TCA cycle) - hsa00020 (Graphviz view) [pdf] - hsa00020 (KEGG view) [png] Pentose phosphate pathway - hsa00030 (Graphviz view) [pdf] - hsa00030 (KEGG view) [png] Inositol phosphate metabolism - hsa00562 (Graphviz view) [pdf] - hsa00562 (KEGG view) [png] Fatty acid biosynthesis - hsa00061 (Graphviz view) [pdf] - hsa00061 (KEGG view) [png] Fatty acid elongation - hsa00062 (Graphviz view) [pdf] - hsa00062 (KEGG view) [png] Fatty acid degradation - hsa00071 (Graphviz view) [pdf] - hsa00071 (KEGG view) [png] Steroid biosynthesis - hsa00100 (Graphviz view) [pdf] - hsa00100 (KEGG view) [png] Tryptophan metabolism - hsa00380 (Graphviz view) [pdf] - hsa00380 (KEGG view) [png] D-Glutamine and D-glutamate metabolism - hsa00471 (Graphviz view) [pdf] - hsa00471 (KEGG view) png] Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - hsa0 (Graphviz view) [pdf] - hsa00532 (KEGG view) [png] Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - hsa00563 (Graphviz view) [pdf] - hsa05630 (KEGG view) [png] Nicotinate and nicotinamide metabolism - hsa00760 (Graphviz view) [pdf] - hsa07600 (KEGG view) [png] RNA polymerase - hsa03020 (Graphviz view) [pdf] - hsa03020 (KEGG view) [png] Ribosome - hsa03010 (Graphviz view) [pdf] - hsa03010 (KEGG view) [png] Protein export - hsa03060 (Graphviz view) [pdf] - hsa03060 (KEGG view) [png] Ras signaling pathway - hsa04014 (Graphviz view) [pdf] - hsa04014 (KEGG view) [png] Phosphatidylinositol signaling system - hsa04070 (Graphviz view) [pdf] - hsa04070 (KEGG view) [png] PI3K-Akt signaling pathway - hsa04151 (Graphviz view) [pdf] - hsa04151 (KEGG view) [png] AMPK signaling pathway - hsa04152 (Graphviz view) [pdf] - hsa04152 (KEGG view) [png] mTOR signaling pathway - hsa04150 (Graphviz view) [pdf] - hsa04150 (KEGG view) [png] Cell adhesion molecules (CAMs) - hsa04514 (Graphviz view) [pdf] - hsa04514 (KEGG view) [png] Autophagy - animal - hsa04140 (Graphviz view) [pdf] - hsa04140 (KEGG view) [png] Cell cycle - hsa04110 (Graphviz view) [pdf] - hsa04110 (KEGG view) [png] Apoptosis - hsa04210 (Graphviz view) [pdf] - hsa04210 (KEGG view) [png] p53 signaling pathway - hsa04115 (Graphviz view) [pdf] - hsa04115 (KEGG view) [png] Signaling pathways regulating pluripotency of stem cells - hsa04550 (Graphviz view) [pdf] - hsa04550 (KEGG view) [png] Regulation of lipolysis in adipocytes - hsa04923 (Graphviz view) [pdf] - hsa04923 (KEGG view) [png] Adipocytokine signaling pathway - hsa04920 (Graphviz view) [pdf] - hsa04920 (KEGG view) [png] PPAR signaling pathway - hsa03320 (Graphviz view) [pdf] - hsa03320 (KEGG view) [png] Longevity regulating pathway - hsa04211 (Graphviz view) [pdf] - hsa04211 (KEGG view) [png] Thermogenesis - hsa04714 (Graphviz view) [pdf] - hsa04714 (KEGG view) [png] Central carbon metabolism in cancer - hsa05230 (Graphviz view) [pdf] - hsa05230 (KEGG view) [png] Type II diabetes mellitus - hsa04930 (Graphviz view) [pdf] - hsa04930 (KEGG view) [png]
Supports deep restorative sleep and improved sleep efficiency
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Tirzepatide's powerful gastric emptying effects combined with cagrilintide's even stronger gastric slowing could create severe GI complications
