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understanding these characteristics facilitates the design of pharmaceutical formulations: In practical use, lyophilized powder is typically reconstituted with water for injection or physiological saline and used immediately
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Adequate stomach acid is required for pancreatic proteases to cleave the B12 from the meat and for subsequent absorption via intrinsic factor
However, some transporters, including OATP1B1/3 and OAT3, demonstrated inhibition following treatment with GLP-1 RAs and a dual GLP-1/GIP RA in vitro, suggesting that the assessment of transporter-mediated DDI by GLP-1 RAs may be necessary (Table 3)
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