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Individuals with EOT2D tend to exhibit higher rates of diabetes remission and more substantial weight reduction following bariatric surgery, suggesting a heightened therapeutic benefit in this subgroup [26,70]
The presence of thyroid peroxidase (TPO) antibodies or thyroglobulin antibodies supports an autoimmune aetiology but is not essential for diagnosis
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In macrophages, its activation is mediated through the MYD88-TICAM1-PI3K-AKT signaling cascade
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