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Tirzepatide is primarily excreted by the kidneys, so reduced renal function could theoretically affect its pharmacokinetics and efficacy (Velenosi and Urquhart, 2014)

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For example, one study found that people aged 65 to 85 who ate five or more servings of fruit and vegetables per day showed a significantly stronger response to a pneumococcal vaccine than people of the same age who ate only two servings of fruit and vegetables or fewer

Infections of the hypothalamic-pituitary region, in: Endotext (2021)

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Therefore, elucidating the relationship between glutamine metabolism and apoptosis, as well as the molecular mechanism, is imperative