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However, prolonged exposure of cells to high-glucose environments can lead to decreased expression levels of Pdx1 and MafA, potentially inhibiting insulin biosynthesis and secretion (Kaneto and Matsuoka, 2015)

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Published online April 1, 2006

Above 10%, documented risks shift into serious territory: severe electrolyte collapse, cardiac strain from reduced stroke volume, impaired thermoregulation, reduced kidney filtration, and acute injury