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[4] In patients with cyanide poisoning, hydroxocobalamin also acts as an antidote by binding to cyanide ions with high affinity to form nontoxic cyanocobalamin
While parenteral B-12 therapy is generally safe, specific populations and medical conditions carry elevated risk
Medications: acid-reflux drugs (PPIs) and some diabetes medications (such as metformin) can interfere with B12 absorption
For a deltoid injection, a five-eighths-inch needle can be enough for a smaller adult, while a larger arm needs a 1-inch needle or longer to be sure the dose reaches muscle
It depends on the tissue
If your protocol is headed toward these higher doses, switching to the 1ml reconstitution when you move past 5mg simplifies the process
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