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The intestinal enzymatic degradation which the GSH is subjected to, leads to its poor absorption and a low bioavailability and requires a very long oral GSH supplementation in order to appreciate a possible increase of its levels
doi: 10.1111/j.1471-4159.1987.tb05654.x
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Glutathione aids in the breakdown of oxidized fats and is necessary for carbohydrate metabolism
Certain medications which can trigger pigmentation as a side effect
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