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Tesamorelin acetate administration to rats during organogenesis and lactation resulted in hydrocephalus in offspring at a dose approximately two and four times the clinical dose, respectively, based on measured drug exposure (AUC)

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Scouten WH, Visser AJ, Grande HJ, De Kok A, De Graaf-Hess AC, Veeger C

Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

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Genetic Predisposition: Family history may increase susceptibility