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HGH injections create supraphysiological spikes followed by rapid decline Side effect profiles differ significantly: Published data shows secretagogues have milder side effects (injection site reactions, mild water retention) compared to HGH (joint pain, insulin resistance, potential organ enlargement at high doses) Regulatory status differs: HGH (somatropin) is FDA-approved for specific conditions
Am J Physiol Endocrinol Metab (2015) 308(8):E6419
The real answer is a lot simpler than you might imagine
doi:10.1186/s12933-022-01604-7 26
IGF-1 LR3 IGF-1 is the hormone that actually does much of the downstream anabolic work, driving muscle protein synthesis
Beyond weight loss, GLP-1 agents reduce circulating insulin levels, attenuate insulin-like growth factor signaling, and lower systemic inflammatory markers
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