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GLP1R agonists increase heart rate and might not be beneficial in individuals with severe left ventricular dysfunction, reduced ejection fraction and/or a history of repeated hospitalization for heart failure

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FIGURE 4 4 Discussion Repeated administration of LIR significantly reduced body weight gain and food consumption in rats subjected to the short-access METH self-administration paradigm

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Melanotan II is a synthetic analogue of the naturally occurring alpha-melanocytestimulating hormone