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Clinical evidence of the effect of GLP-1RAs on skeletal muscle mass Clinical effects of GLP-1RAs on body composition and lean body mass Multiple clinical studies have confirmed that glucagon-like peptide-1 receptor agonists have significant effects in reducing overall weight and fat mass

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Clinical implications and biomarker development Liquid biopsy for dynamic monitoring: ctDNA, circulating tumor cells (CTCs), and exosomes Liquid biopsy, through the analysis of ctDNA, CTCs, and extracellular vesicles (EVs) in peripheral blood or other body fluids, provides a minimally invasive and real-time approach for early cancer detection, treatment monitoring, and resistance mechanism identification (Fig

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