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For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

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45 Currently, the strategy of multiple receptor stimulation is actively expanding indications in metabolic disorders, particularly in MASLD, and some medications have reported more potent therapeutic efficacy compared to single GLP-1RA

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