Other neuroprotective mechanisms potentially involved in the treatment of cognitive disorders as well as cerebrovascular disease and epilepsy suggest that GLP-1RAs can enhance the viability of neurons and restore neurite outgrowth by stimulating neurotrophic factors, thus increasing subventricular zone progenitor cells, decreasing apoptosis and the level of pro-inflammatory factors, and strengthening the bloodbrain barrier 37
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However, individual circumstances vary, and factors such as gastrointestinal side effects, medication absorption, and overall seizure control require careful consideration
An interesting difference between the hippocampus and the cortex was that we observed higher levels of hippocampal myelin cofactors pantothenate and choline