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The cyclic structure is maintained by the disulfide bond, which is susceptible to oxidative cleavage in the presence of dissolved oxygen, light exposure, and temperatures above 8C

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doi:10.1111/j.1365-2125.2004.02194.x 111

Among them sodium handling is probably the best described (Krekels et al., 2015)

Despite some clinical setbacks, continued development of HAPs with improved hypoxia specificity and reduced toxicity remains a vibrant area of cancer research

Those who are pregnant, nursing, or taking medications should consult a healthcare professional before use to ensure safety and appropriate dosing.