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The index variant is in near perfect linkage disequilibrium ( r 2 = 0.99) with a missense variant within GIPR (rs1800437, P = 5.1 10 9

Biochem Soc Symp

Meet clinical BMI criteria and have no contraindications: If your BMI is 30 or higher (or 27+ with weight-related health conditions), and you don't have personal or family history of medullary thyroid cancer, Multiple Endocrine Neoplasia syndrome type 2, or other contraindications listed in the safety information, you may be a medically appropriate candidate for GLP-1 treatment

It is distinguished from its successors primarily by its pronounced appetite-stimulating effects, the strongest of any GHRP, and its broader hormonal footprint that includes modest elevations in cortisol and prolactin at higher doses

2023, 102393, Liu, Yixun, et al

But you might not anticipate how it can influence your emotions