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PMID: 36321012
Through preclinical and phase I clinical trials, AMG 133 has demonstrated significant weight reduction and improvement in various metabolic parameters, paving a new path for the treatment of obesity and other related metabolic diseases
In addition, we designed a matching prodrug, PARx, that uses the same S N Ar chemistry to release a chemotherapeutic with an integrated PA readout
Am J Physiol Gastrointest Liver Physiol 310: G26-33, 2016
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