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Nrf2 is a major regulator of the cellular oxidative stress response and maintenance of redox homeostasis (Ma, 2013), and is regulated by signaling pathways such as NF-B, Notch, PI3K-AKT, and Brca-1 (Li et al., 2023a), with the PI3K/AKT signaling pathway being a sensory hair cell important regulator for survival against oxidative stress (Wang X
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J Nephrol
Collagen is also not recommended for those diagnosed with collagenosis , a chronic systemic connective tissue disease
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