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While large human trials are pending, preclinical and mechanistic evidence is strong
Leukemia 24 , 15881598 (2010)
Chen MC, Ye YI, Guang JI, Jian, Liu JW (2010) Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells
However, supplementation should be approached with caution and must strictly follow a doctor's recommendations
Furthermore, CAF-derived exosomes, which carry acetic acid, lipids, amino acids, or TCA intermediates, are taken up by pancreatic cancer cells via macropinocytosis and are associated with the inhibition of mitochondrial oxidative phosphorylation and increased compensation of glycolysis
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