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Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
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This early combination therapy with drugs targeting different actions provided better blood glucose control, decreased treatment failure, and extended the time to initiating insulin therapy [100]
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The tradeoff is that the multi-receptor activity is locked into the molecule rather than adjustable by mixing
Epub 2015 May 7
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