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Interestingly, although exendin-4 up-regulated adiponectin expression in adipocytes (Fig 4B), the treatment did not recover the circulating adiponectin concentration in mice fed with high fat diet to a level comparable to mice fed with normal chow (Fig 4C)

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We also saw that with placebo supplementation, the levels of oxidized GSH significantly increased, while levels of reduced GSH significantly decreased in all blood components

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