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The Gpx family of glutathione peroxidases is an evolutionarily highly conserved group of enzymes containing eight main isoenzymes, among which Glutathione Peroxidase 4(GPx4) utilizes GSH as a cofactor to convert lipid hydroperoxides into nontoxic lipids alcohols and reduce free radical accumulation (36)

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[4] It is a tripeptide composed of L-cysteine, glycine and glutamate that is synthesised intracellularly

10.1016/j.cub.2013.09.001 38 IssacM