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Medication: Oral contraceptives and certain chemotherapy medication cause hormonal fluctuations

Retatrutide activates three, targeting GLP-1, GIP, and glucagon receptors simultaneously, which is why Eli Lilly calls it a "triple agonist." This triple mechanism is also why the dose schedule matters more than with any other weight loss peptide on the market

This is not a reason to avoid GLP-1 therapy

An oral product avoids injection-site pain, bruising and the low risk of anaphylaxis

As shown in Table 2

Some insurance companies cover semaglutide for type 2 diabetes treatment, but it may not cover it for weight loss purposes