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Fu, H., Kong, B., Zhu, J., Huang, H

In two studies, oral administration of estradiol caused an increase in total daily GH secretion and its pulsatile release and a decrease in plasma IGF-I levels, whereas transdermal estrogen treatment increased circulating levels of IGF-I in post-menopausal to that seen in pre-menopausal women without altering the pulsatile release of GH [145, 146]

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In human research of chronic insomniacs DSIP had normalizing influence on sleep regulation

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Cycling prevents desensitization and supports long-term effectiveness