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224 Another important consideration is the psychological toll to both partners of pursuing expensive, invasive procedures without a guarantee of success

The foundational U-shaped dose-response relationship was also documented in this original research programme

The authors concluded that radiation therapy, which has similar recurrence rates to surgery, was the best alternative.73 Based on a survey conducted among British dermatologists in 2001, the most common nonsurgical treatments were cryotherapy and radiation therapy.74 The general limitations of nonsurgical treatments are summarized below

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