Klotho mimetics can theoretically suppress phosphate reabsorption in the kidneys, and if KLOW replicates this effect at high doses, the result is phosphate depletion that manifests as muscle weakness, bone demineralization, and in severe cases, rhabdomyolysis
Methods Ethics statement The Ethics Committee (IRB) of Oilfield General Hospital (Daqing City, Heilong Jiang Province, China) recognizes that this systematic review and meta-analysis of de-identified, publicly available data does not constitute human subjects research as defined by relevant national regulations, and therefore does not require Ethics Committee review
Always consult with your physician before beginning any therapy program
For a broader survey of published preclinical findings and study design considerations, the BPC-157 research overview consolidates the current experimental landscape
(2016) Magnesium intake and depression: the SUN cohort