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A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimers disease
In a lipopolysaccharide (LPS)induced endotoxemia mouse model, oral Mito-Apo markedly reduced systemic oxidative markers (e.g., 4-HNE) and preserved mitochondrial function, while standard apocynin showed minimal efficacy (Padhi et al., 2019)
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