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doi: 10.1039/C6MT00058D 215 PolymenidouM.Lagier-TourenneC.HuttK
Biodistribution and therapeutic effects in orthotopic osteosarcoma mouse model Based on these promising findings, the biosafety of Ru(II)-OH, NP2, or NP4 at a doses of 2 mg Ru/kg was studied upon intravenous injection into the tail vein of healthy female mice on the days 1, 4, and 7
Using cell culture models and molecular analysis techniques including cDNA microarray, RT/real-time PCR, and Western blotting, researchers demonstrated that BPC-157 treatment upregulates GHR expression in a dose- and time-dependent manner at both the mRNA and protein levels
Intriguingly, in the trx3 , trr2 , and prx1 strains we observed either no E GSH response ( prx1 ) or an E GSH response that was greatly decreased compared to wildtype cells ( trx3 , trr2 ), following the addition of exogenous H 2 O 2 at an initial concentration of 1 mM (Fig 3A)
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