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10.1161/CIRCINTERVENTIONS.110.960476 213

167 Evasion of apoptosis brought about by H 2 S has been attributed mostly to CSE-generated H 2 S mediating the per-sulphidation of key proteins in different signalling pathways: nuclear factor-B (NF-B) in hepatoma cells, 168 the Keap1-transcriptional regulator of NRF2, 169 and the extracellular-signal-regulated kinase (ERK)-activating protein kinase 1

Studies suggest that AOD9604 does not bind the growth hormone receptor and does not activate the JAK2/STAT5 pathway, which accounts for the absence of growth-promoting or IGF-1-elevating effects observed in animal studies

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