GLP-1RAs, as an important class of drugs for the treatment of T2DM, shows significant advantages in blood glucose control, weight loss, cardiovascular protection and kidney benefit (Ussher and Drucker, 2023
The condition likely results from some combination of genes (up to half of people with melasma have or had a close relative with melasma), hormonal changes and sun exposure
For prescription fills exceeding a 30 day supply, we assumed supply extended across subsequent months (e.g., a 60-day fill was counted as two months of supply)
Eligibility generally includes a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with a weight-related condition (such as high blood pressure, type 2 diabetes, or abnormal cholesterol)
The dual mechanism targeting insulin resistance is the theoretical reason this works, and the clinical picture is consistent
It works on 3 receptors that are involved in glucose metabolism and appetite regulation: glucagon-like peptide-1 (GLP-1) receptor, glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor