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For Study 6, the primary efficacy parameters were mean percent change in body weight and the percentage of patients achieving greater than or equal to 5% weight loss from baseline to Week 68

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Also, RONS themselves decrease the activity of the antioxidant enzymes, including CAT and GPx activity [59], and copper (Cu)/zinc (Zn)-SOD is reported to be inactivated by the glycation of specific lysine residue during hyperglycemia [60]

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