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Its well-characterized tetrapeptide structure and expanding scientific literature make it valuable for analytical method development, formulation comparison studies, laboratory quality assurance, and molecular investigations

This is particularly important in neurodegenerative diseases where oxidative stress is a contributing factor

Fundamentally, AuNCs are intriguing functional nanomaterials with a precise molecule-like structure (comprising a discrete number of gold atoms and protecting ligands) and considered as the missing link between molecules and nanoparticles 16

Such mechanism has been demonstrated using several free thiols blocking agents and/or protein disulfite isomerase inhibitors

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For example, TAT3 inhibitor nanoparticles (MPNPs) in conjunction with oncolytic viruses can activate GSDME-dependent pyroptosis and markedly enhance the efficacy of anti-PD-1 therapy [62]