A case of Stevens-Johnson syndrome and toxic epidermal necrolysis has been reported following intravenous infusion of glutathione combined with vitamin C in a 2025 case report by Johnson, Jarvis, and colleagues in the Journal of Burn Care and Research
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These adverse effects, including peripheral neuropathy and hearing loss, can have a profound impact on patient quality of life and require careful monitoring throughout treatment [44, 45]
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Unlike fat-soluble vitamins (A, D, E, and K) that can build up, B12 has a strong safety record and toxicity is rare