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Animal toxicology signals Two animal findings reviewed by FDA are worth tracking even if they did not surface clinically

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However, data on dermal irritation by copper and its compounds are scant and the role of copper as an irritant/sensitizer remains controversial 3

Chronic alcoholism in rats induces a compensatory response, preserving brain thiamine diphosphate, but the brain 2-oxo acid dehydrogenases are inactivated despite unchanged coenzyme levels

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