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642 Additionally, lactate secretion during glycolysis lowers the pH of the TME, 643 increasing invasive capacity

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5153 Notably, of the different HF phenotypes, HFpEF is associated with the worst HRQoL, whereas among HFpEF patients, the worst HRQoL had been shown in a subgroup with the highest BMI, a higher proportion of at least Grade 2 obesity and T2D

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