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Key Insights Fatigue is a common but usually temporary side effect during the initial weeks or dose changes in GLP-1 therapy, caused largely by rapid calorie deficit, dehydration, and metabolic adjustments. Maintaining steady energy requires prioritising nutrient-dense meals rich in protein and complex carbohydrates, staying well hydrated, and managing electrolyte balance, which helps mitigate tiredness and supports overall metabolism. Gentle physical activity and good sleep hygiene are critical lifestyle adjustments that improve circulation, mood, and energy levels without overtaxing the body during the drug adaptation period. Persistent, worsening, or debilitating fatigue should prompt medical evaluation to exclude other causes, reassess medication dosing, and ensure safe continuation of GLP-1 therapy under healthcare supervision. Frequently asked questions Why do GLP-1 medications cause fatigue

If your symptoms match the second list, your dose is likely too high and requires medical attention

Careful dose escalation under medical supervision helps minimise side effects and improves long-term tolerability

It's typically mild and doesn't usually lead to discontinuation, but it's real and unique to retatrutide

Tell your health care professional if you experience new or worsening depression, suicidal thoughts, or any unusual changes in mood or behavior

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