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This includes specialty nutrition products such as ketones or supplements/vitamins

This function is mediated via the activation of the cAMP/PKA/CREB (cAMP-responsive element binding protein) and the transactivation of the EGF-R (epidermal growth factor receptor) leading to the activation of phosphatidylinositol-3 kinase (PI3K), protein kinase C(PKC), Akt-protein kinase B (AKT/PKB), extracellular regulated kinase (ERK1/2 or mitogen-activated protein kinase [MAPK]) signaling pathways and to the up-regulation of the expression of the cell cycle regulator cyclinD1 (Figure 3)

PT-141 also has moderate affinity for MC1R (the pigmentation receptor) and negligible activity at MC2R (the cortisol-axis receptor) or MC5R

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Foster C, Baki J, Nikirk S, Williams S, Parikh ND, Tapper EB