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- November 14, 2024 - Mayo Clinic research at Obesity Week 2024 demonstrates precision medicines role in transforming obesity prevention

Why Results Differ Semaglutide and dulaglutide differ in their molecular structure, affecting potency: Semaglutide: Modified structure for enhanced receptor binding Longer half-life and more stable blood levels Greater receptor activation at comparable doses Dulaglutide: Linked to IgG4 antibody fragment to extend half-life Effective but less potent than semaglutide Longer track record (approved earlier) These structural differences explain why semaglutide produces greater effects despite both being weekly GLP-1 medications

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This same action that reduces hunger also slows digestion, allowing food to sit longer in your gastrointestinal tract