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The noncanonical pathway is stimulated by cytokines such as CD40L or BAFF, involving NIK-mediated processing of p100 to p52 and formation of RelB/p52 dimers that translocate into the nucleus

In the mitochondria, the "power plants" of the cell, a series of complex biochemical reactions take place

J Exp Med (2021) 218(6):e20210518

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Phase II detoxification is where the body takes reactive, dangerous intermediates created by Phase I and converts them into water-soluble molecules that can be excreted through bile, urine, and stool