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Oral Wegovy (semaglutide 25 mg): the first approved oral GLP-1 for weight loss On December 22, 2025, the FDA approved oral Wegovy, making it the first and only oral GLP-1 medication approved specifically for weight management in adults

This helps your healthcare provider give advice that fits your needs and may help them change your treatment plan if needed

Injection site reactions: Both compounds, if used in injectable form, carry risks of localised reactions including redness, swelling, pain, and infection

[02:47-03:11] So some of these patients are getting powder and they're mixing them with like, you know, sterile water to try to inject themselves and they're mistaking micrograms for milligrams and whoops, I'm getting way too much and suddenly I'm sick

Common side effects (affecting more than 1 in 10 people) include: Nausea and vomiting : Often most pronounced in the first few weeks Diarrhoea or constipation : Gastrointestinal motility changes are expected Decreased appetite : This contributes to weight loss but may be uncomfortable Abdominal pain or discomfort Injection site reactions : Redness, itching, or swelling at the injection site To minimise gastrointestinal symptoms, patients should eat smaller, more frequent meals, avoid high-fat foods, and stay well hydrated

While this medication has helped many people reduce body weight and improve health markers, determining the ideal dose isnt the same for everyone