Indeed, there are multiple primary or secondary bile acid chemosensors in the liver (348, 354) or scattered along the gastrointestinal tract (355), where they ensure a direct negative feedback aiding detoxification (356) and protecting from hepatotoxicity and carcinogenicity displayed by some secondary bile salt such as lithocholic acid
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At Perfect B, the decision to prescribe them together versus as standalone protocols depends on the patients injury profile, the acuity of the damage, and the timeline for recovery