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(6) Increased bone marrow adipose tissue accumulation and altered mesenchymal stem cell differentiation contribute to reduced osteoblast activity, increased osteoclastic resorption, and an overall decline in bone strength, leading to a greater fracture risk despite higher bone mineral density measurements

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Application: Injection Sites : Common sites for IM injections include the deltoid muscle (upper arm), the gluteus maximus (buttocks), and the vastus lateralis (thigh)

Others have moved in the opposite direction, limiting coverage due to budget concerns

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