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The inhibitor of mGlu2/3 receptor (LY341495) blocked the NAC-induced inhibition of both relapse ethanol intake and neuroinflammation without affecting the GSSG/GSH ratio
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However, oral reduced glutathione faces challenges with absorption
Randomisation was 21:3:3:7 to cagrilintidesemaglutide 2.4/2.4 mg (n=2108), semaglutide 2.4 mg alone (n=302), cagrilintide 2.4 mg alone (n=302), or placebo (n=705), all with lifestyle intervention [7]
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