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UVvis spectra were acquired using a Multiskan SkyHigh microplate spectrophotometer (ThermoFisher Scientific) and 96-well plates (Corning) or quartz cuvettes using SkanIt software

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Key Takeaways Faulty one-way valves in leg veins allow blood to flow backward and pool, creating the characteristic rope-like, bluish appearance that affects up to 35% of Americans

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We also examined our outcomes after adjusting for mean hemoglobin A1c during follow up, use of other classes of glucose-lowering medications, and number of glucose-lowering medication classes used during follow up period

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Understanding these causes is essential for appropriate clinical management and avoiding unnecessary alarm

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In the pathology of septicemia, pathogen-associated molecular patterns activate NOX2 [410], triggering an electrogenic respiratory burst that pumps O 2 into phagosomes

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