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[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management
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Other secondary criteria of efficacy assessing the benefit on LDRC included change in MDS-UPDRS 24 fluctuations with dyskinesia and dystonia part IV (the highest being the worst)
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